76%
Bone Mineral Density
Pelvic bone density analysis, hip-luxated retriever
Before
After 4 weeks
Research · Clinical & Scientific Evidence
The Science of JOINT WIN,
The Science of JOINT WIN,
Proven in Papers and Patents
The patented JOINT WIN complex is backed by eight international journal papers published since 2010,
patents granted in Korea, the United States and China, and clinical data in dogs.
Clinical Data · Change You Can Measure
4 Weeks, Measurable Results
Changes in joints and muscle observed within a short feeding period.
60%
Patellar Pain Index
Dogs with patellar luxation, after feeding Bone to Pet Up
Before
After 4 weeks
12%
Muscle Mass
Same test group, after 4 weeks of feeding
Before
After 4 weeks
Source · Bone density analysis, National Institute of Animal Science
Research · The Story of the Patent
Six Years of Research,
Six Years of Research,
Published Internationally
The WIN-34B (honeysuckle · Anemarrhena) and BHH10 (Astragalus · cassia twig · Phellodendron)
complexes have been verified in international peer-reviewed journals.
2010
Analgesic
Pain Relief and Anti-Inflammatory Effect
In an osteoarthritis animal model, the honeysuckle and Anemarrhena complex (WIN-34B) reduced pain and inflammation.
Published in · Journal of Ethnopharmacology
2011
Gastric Safety
Gastric Safety Demonstrated
Unlike synthetic NSAIDs, it was shown to be safe for long-term feeding without damaging the gastric lining.
Published in · Journal of Ethnopharmacology
2012
Cartilage Protection
Mechanism of Cartilage Protection
It suppresses cartilage-degrading enzymes (MMPs) and inflammatory mediators, limiting cartilage damage.
Published in · BMC Complementary Medicine and others
2013
Regeneration
Cartilage Protection and Regeneration
In an osteoarthritis animal model it protected cartilage tissue and promoted differentiation of cartilage progenitor cells.
Published in · Evidence-Based Complementary and Alternative Medicine
2014
Marker Compound
Action of the Key Marker Compound
The pathway by which the marker compound mangiferin supports cartilage differentiation of stem cells was mapped at molecular level.
Published in · International Journal of Molecular Sciences
2014
Bone Density
Recovery of Bone Mineral Density
The Astragalus, cassia twig and Phellodendron complex (BHH10) restored bone density and bone mass in an osteoporosis animal model, improving bone structure over an existing treatment without toxicity.
Published in · Phytotherapy Research
2016
Bone Formation
Promotion of Bone Formation
A dual action was confirmed: supporting the cells that build bone while suppressing the cells that break it down.
Published in · Journal of Ethnopharmacology
2016
Clinical Stage
Phase II Trial Protocol Registered
A multicentre, randomised, double-blind, placebo-controlled phase II trial protocol for BHH10 was published in an international journal. (KCT0001842)
Published in · Trials
These are research findings on the raw-material complexes (WIN-34B · BHH10) and do not guarantee the efficacy of the finished product.
Publications · Peer-Reviewed Papers
Research Findings
Research Findings
at a Glance
Findings by year, and the journals that published them.
2010
Analgesic
Pain Relief and Anti-Inflammatory Effect
In an osteoarthritis animal model, the honeysuckle and Anemarrhena complex (WIN-34B) reduced pain and inflammation.
Journal of Ethnopharmacology
2011
Gastric Safety
Gastric Safety Demonstrated
Unlike synthetic NSAIDs, it was shown to be safe for long-term feeding without damaging the gastric lining.
Journal of Ethnopharmacology
2012
Cartilage Protection
Mechanism of Cartilage Protection
It suppresses cartilage-degrading enzymes (MMPs) and inflammatory mediators, limiting cartilage damage.
BMC Complementary Medicine and others
2013
Regeneration
Cartilage Protection and Regeneration
In an osteoarthritis animal model it protected cartilage tissue and promoted differentiation of cartilage progenitor cells.
Evidence-Based Complementary and Alternative Medicine
2014
Marker Compound
Action of the Key Marker Compound
The pathway by which the marker compound mangiferin supports cartilage differentiation of stem cells was mapped at molecular level.
International Journal of Molecular Sciences
2014
Bone Density
Recovery of Bone Mineral Density
The Astragalus, cassia twig and Phellodendron complex (BHH10) restored bone density and bone mass in an osteoporosis animal model, improving bone structure over an existing treatment without toxicity.
Phytotherapy Research
2016
Bone Formation
Promotion of Bone Formation
A dual action was confirmed: supporting the cells that build bone while suppressing the cells that break it down.
Journal of Ethnopharmacology
2016
Clinical Stage
Phase II Trial Protocol Registered
A multicentre, randomised, double-blind, placebo-controlled phase II trial protocol for BHH10 was published in an international journal. (KCT0001842)
Trials
Full papers can be found on academic search engines under the complex names (WIN-34B · BHH10).
Patents · Registered
Patented in
Patented in
Korea, the US and China
Ingredient patents held jointly with Kyung Hee University and Whanin Pharm.
KR
KR Patent No. 10-1072264
Composition for the prevention and treatment of arthritis · Granted 2011
KR
KR Patent No. 10-1193540
Composition for the prevention and treatment of osteoporosis and bone diseases · Granted 2012
US
US 2011-0003018
United States patent
CN
CN 101939018
Chinese patent (invention patent ZL 2009-8-0104672.4)
Certificate of Patent
Scans of the original patent certificates. Click any document to view it at full size.
FAQ · Clinical & Research
When do the effects show?
It varies by animal, but many owners report a change in movement from around four to eight weeks of consistent feeding. Joint health builds up over time, so we recommend feeding continuously for at least three months.
From what age can it be fed?
From six months of age. It is especially worth starting early for dogs that hesitate on stairs, very active dogs, and dogs entering their senior years.
How many pieces a day?
One piece a day under 5 kg, two pieces for 5 to 15 kg, and three pieces over 15 kg. Feeding a little more is not harmful, but the recommended amount is best.
How was the clinical study run?
Dogs with patellar luxation were fed for four weeks with pain-index assessment, X-ray, haematological analysis and muscle-mass measurement. Pain index fell by 52% and muscle mass rose by 10%.
Where can I read the papers?
Eight papers on the raw-material complexes (WIN-34B · BHH10) have been published in international journals including the Journal of Ethnopharmacology. Search academic databases under the complex names.
Is long-term feeding safe?
A gastric safety study found markedly less gastric damage than conventional anti-inflammatory drugs, and non-toxicity has been reported. As a botanical material it carries little long-term feeding burden.